Intellectual Interdisciplinary Support System for Making Medical Decisions in the Diagnosis of Inorganic Retroperitoneal Tumors

The paper considers the creation of the intellectual support system of medical decisions of inorganic retroperitoneal tumors. The system is focused on improvement ofdiagnostics quality ofinorganic retroperitoneal tumors - one of the most difficult at diagnosing at early stages among oncologic patients

Intellectual Information and Training System for Software and Hardware Complexes of Morphological Diagnostics of Esophageal Tumors

The aim of the work is to create a system of formalizing knowledge in the histological diagnosis of esophageal tumors and systematic transfer of knowledge to less experienced specialists. It is also a system that will provide support in making a decision in a histological diagnosis. Keywords: esophagus, morphological, automatic work place, system of support for the solutio

Expert System for Histological Diagnosis of Prostate Cancer

The paper is dedicated to the development of expert system for histological prostate cancer diagnosis. The developed system allows to fill the knowledge base and then to use this knowledge base to support physician decision on the histological diagnosis of prostate disease. Keywords: pattern recognition, prostate cancer diagnosis, decision making, decision support syste

System Approach to the Development of Intelligent Complexes of Oncological Diagnostics

The system approach to the development of intellectual complexes in cancer diagnosis are discussed in the article. Distinctive features of this approach: the participation of pathologist at the stage of description of recognizable images (the description is based on traditional assessments of quality informative features of tumors); the set of the most similar probabilistic diagnoses is forming on the classification stage of recognition; final histological diagnosis is made by pathologist. The proposed approach has been successfully tested in clinical practice. Keywords: image processing, image description, image classification, pattern recognition, qualitative attributes of tumor images, interactive recognition, cancer diagnosis, decision support syste

Method of Myelogram Analysis in Leukocyte Recognition Systems

An approach for the formation of a myelogram was proposed. It is based on digital image processing and pattern recognition. It is used in automated analysis of blood smears and bone marrow. The proposed approach is implemented in an automated recognition system of blood cells. The effectiveness of the proposed approach was evaluated. Keywords: Computer microscopy, image processing, segmentation, blood cells recognition, acute leukemi

Primary multiple BRCA associated breast cancer and ovarian cancer (clinical case)

Introduction. The study of mutation in BRCA1/2 genes was first initiated in the USA and Europe, and later in Russia. Statistics indicate that women with the BRCA1/BRCA2 mutation have a higher risk of breast and/or ovarian cancer than the general population. According to different authors, the average cumulative risk among BRCA1 carriers is 65% (range 44–78%) for breast cancer and 39% (range 18–54%) for ovarian cancer. For mutation carriers in the BRCA2 gene, the risk for breast cancer is 45–49%, while the risk for RNA is 11–18%. However, in patients already diagnosed with breast cancer or ovarian cancer, the risk of a second tumor persists throughout life and may remain high even in old age. Treatment of BRCA-associated breast cancer and/or ovarian cancer is almost the same as treatment for sporadic cancer, and includes surgical, radiation, and drug anticancer therapy. However, there are some features that need to be considered in clinical practice. Clinical case. In this article we present the clinical experience of the treatment of a 32-year-old patient with BRCA1-associated primary multiple synchronous breast cancer and metachronous uterine tube cancer. In July 2015, the patient was diagnosed with synchronous cancer of both breast (Luminal A right breast cancer and Luminal B left breast cancer). As part of a treatment and with the patient’s consent, a bilateral adnexectomy was performed. In the histological examination of the operating material, the uterine tube cancer was diagnosed in situ. From 16.03.2016 to the present time the patient receives adjuvant endocrinotherapy without signs of disease progression. Conclusion. This clinical case study presents the importance of a combined approach to the treatment and prevention of BRCAassociated cancer